A neuroscience perspective on anxiety proneness - Sex differences, monoaminergic pathways and treatment response

• Conditions: Men and women diagnosed with DSM-IV social phobia (social anxiety disorder); MedDRA version: 14.0Level: LLTClassification code 10041242Term: Social anxiety disorderSystem Organ Class: 10037175 - Psychiatric disorders

• Registration Number: EUCTR2010-023007-10-SE
• Lead Sponsor: ppsala university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-05
• Last Update Posted: 28 August 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Social anxiety disorder (social phobia), according to DSM-IV, must be the main diagnosis as assessed with the structured clinical interview for DSM disorders

2. Otherwise somatically healthy

3. Age 18 or older but not postmenopausal

4. Willingness to participate in a symptom provocation brain imaging trial

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

1. Treatment of social anxiety within the three months preceding the study

2. Current serious or dominant psychiatric disorder other than social anxiety disorder (e.g., psychosis, major depressive disorder, bipolar disorder)

3. Suicidal ideation

4. Chronic use of prescribed medication that could influence the results

5. Abuse of alcohol or narcotics

6. Pregnancy or planned pregnancy during the study period

7. Menopause

8. Previous PET examination

9. Contrainidications for MRI investigations (e.g. implants or other metal objects in the body, brain and heart operations)

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified