Midkine Interplays With Oxidative Stress and Inflammatory Milieu to Induce Preeclampsia in Normotensive Pregnant Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Severity of Pre-Eclampsia (PE)
研究概览
简要总结
Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated.
Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Newly pregnant normotensive (NT) women with singleton fetus;
- •Free of the Exclusion Criteria.
排除标准
- •Women with history of complicated pregnancy;
- •Had manifest essential hypertension, Diabetes Mellitus or chronic kidney diseases;
- •Had multiple gestational sacs, morbid obesity with Body Mass Index at time of pregnancy diagnosis over 35 kg/m2;
- •Had genetic disorders, coagulopathy, autoimmune diseases or maintained on immunosuppressive therapy.
研究组 & 干预措施
Serum Midkine
干预措施: ELISA (Diagnostic Test)
结局指标
主要结局
Severity of Pre-Eclampsia (PE)
时间窗: 8 months
Correlation between Serum midkine levels and blood pressure measurements
次要结局
未报告次要终点
研究者
Shereen Naguib
Lecturer of Obstetrics & Gynecology, Faculty of Medicine
Benha University