Midkine Interplays With Oxidative Stress and Inflammatory Milieu to Induce Preeclampsia in Normotensive Pregnant Women
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pre-Eclampsia
- Sponsor
- Benha University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Severity of Pre-Eclampsia (PE)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated.
Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils.
Investigators
Shereen Naguib
Lecturer of Obstetrics & Gynecology, Faculty of Medicine
Benha University
Eligibility Criteria
Inclusion Criteria
- •Newly pregnant normotensive (NT) women with singleton fetus;
- •Free of the Exclusion Criteria.
Exclusion Criteria
- •Women with history of complicated pregnancy;
- •Had manifest essential hypertension, Diabetes Mellitus or chronic kidney diseases;
- •Had multiple gestational sacs, morbid obesity with Body Mass Index at time of pregnancy diagnosis over 35 kg/m2;
- •Had genetic disorders, coagulopathy, autoimmune diseases or maintained on immunosuppressive therapy.
Outcomes
Primary Outcomes
Severity of Pre-Eclampsia (PE)
Time Frame: 8 months
Correlation between Serum midkine levels and blood pressure measurements