Weaning From Mechanical Ventilation Guided by Lung Ultrasound (Brazilian WEANLUS)
Phase 3
- Conditions
- Acute Respiratory Failure
- Interventions
- Other: weaning guided by LUS (lung ultrasound)
- Registration Number
- NCT01966861
- Lead Sponsor
- D'Or Institute for Research and Education
- Brief Summary
The present study aims to evaluate the impact of a weaning strategy based on identification of early signs of respiratory distress by lung ultrasound and the consequent implementation of a "clinical optimization" protocol as compared to usual care.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Mechanically ventilated >48h
Exclusion Criteria
- Moderate/Severe COPD
- Spinal cord lesion
- Neuromuscular disease (previous)
- Lung fibrosis
- Tracheostomy
- Heart failure (EF<50%)
- Lung/pleural cancer
- inadequate "window"for LUS
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Weaning guided by lung ultrasound weaning guided by LUS (lung ultrasound) Predictive early signs of respiratory distress are assessed by lung ultrasound and if found will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis)
- Primary Outcome Measures
Name Time Method Respiratory distress requiring re-intubation or non-invasive ventilation 48hours
- Secondary Outcome Measures
Name Time Method Hospital Mortality Hospital death/discharge (up to 60 days) 28-day mortality 28 days Adverse events 48h Renal dysfunction, complications of thoracocentesis, hydro-electrolite changes, hypotension
Trial Locations
- Locations (1)
D'OR Institute for Research and Education
🇧🇷Rio de Janeiro, Brazil