Clinical study on the changes in the vascular endothelial function by the intervention for hypertriglyceridemia in patients with type 2 diabetes treated with statin.

Not Applicable

Recruiting

• Conditions: Type 2 diabetes patients with hypertriglyceridemia

• Registration Number: JPRN-UMIN000016676
• Lead Sponsor: Kagoshima University Graduate School of Medical and Dental Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-03-03
• Study Completion: 2017-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

HbA1c > 8.0%. Patients with severe liver dysfunction. Patients with history of hypersensitivity to study drugs. Serum creatinine >= 2.5 mg/dl. Patients with secondary properties and drug-induced lipid abnormalities. Patients with familial hypercholesterolemia. Pregnancy example. Patients with history of coronary artery disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We compare the lipoprotein profile and FMD(flow mediated dilation) between the two groups(Statin group and Ezetimibe/fenofibrate combination group). we compare also changes in postprandial hypertriglyceridemia.

Secondary Outcome Measures

Name	Time	Method
Before and after Cookies meal test, relation between lipid parameters(total cholesterol, triglycerides, HDL, LDL, LPL, apoprotein) and FMD.