Biomarkers In Retinitis Pigmentosa (BIRP)

Completed

• Conditions: Retinitis Pigmentosa
• Interventions: Other: Anterior Chamber (AC) tap

• Registration Number: NCT01949623
• Lead Sponsor: Johns Hopkins University

Brief Summary

In this study, markers of oxidative stress will be measured in the aqueous humour and plasma of RP patients compared to controls.

Detailed Description

People with Retinitis Pigmentosa have loss of night vision followed by loss of central vision due to damage and death of photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers which can be measured. In this study, these biomarkers will be assessed in people with Retinitis Pigmentosa and compared to controls.

Study Timeline

• Study Start: 2013-09
• Study First Submitted: 2013-09-20
• Study First Submitted QC: 2013-09-23
• Study First Posted: 2013-09-24
• Primary Completion: 2017-06
• Study Completion: 2017-07
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-14
• Last Update Posted: 2017-08-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Signed informed consent and authorization of use and disclosure of protected health information
• Age more than or equal to 18 years
• For the study group, patients diagnosed with Retinitis Pigmentosa by the investigators
• For the control group, patients undergoing vitreoretinal surgery for macular hole, epiretinal membrane, vitreomacular traction, retinal detachment, neovascular Age-related Macular Degeneration (AMD) and Diabetic Retinopathy will be eligible

Exclusion Criteria

• Patients with active or suspected ocular or periocular infection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
RP patients	Anterior Chamber (AC) tap	Retinitis Pigmentosa patients
Controls	Anterior Chamber (AC) tap	Patients who will be undergoing surgery for macular hole, epiretinal membrane, or vitreomacular traction, patients who have a retinal detachment , patients with neovascular age related macular degeneration and patients with diabetic retinopathy.

Primary Outcome Measures

Name	Time	Method
Aqueous levels of markers of oxidative stress in patients with RP and controls.	2 years

Trial Locations

Locations (1)

Wilmer Eye Institute; 🇺🇸 Baltimore, Maryland, United States