Role of Metabolic Syndromes (MetS) in the Incidence of Post-Operative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Surgery under General Anaesthesia: A Prospective Observational Study

Post-Operative Delirium (POD) and Post- Operative Cognitive Dysfunction (POCD) are the common neurocognitive complications that observed in the elderly population after the surgery. The clinical features include deterioration in cognition such as agitation or confusion, during the days after surgery, disturbance in attention, reduced awareness of the environment and greater utilization of social financial assistance. The prevalence of POD and POCD are associated with higher mortality, increased incidence of postoperative complications and longer duration of hospital stay. In about 30-50% cases, even after delirium is resolved, elderly patients are additionally affected by post-operative cognitive dysfunction. Review articles revealed that postoperative delirium and postoperative cognitive dysfunction are multifactorial condition and has been elucidated on the molecular basis with diagnostic biological markers. Therefore, in this study we will assess the complete relation between metabolic disorder and the risk of postoperative delirium (POD) and postoperative cognitive dysfunction in elderly population. The identified biomarkers would be helpful in determining the severity and phase of the cognitive impairment to improve diagnosis and treatment of POD and POCD.