Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS)
- Registration Number
- NCT00647023
- Lead Sponsor
- Hvidovre University Hospital
- Brief Summary
The incretin hormones are secreted from the gastrointestinal tract in response to nutrient ingestion, and are responsible for 70 % of insulin secretion in response to glucose. The incretin response is attenuated in subjects with type 2 diabetes and other conditions associated with insulin resistance. Polycystic ovary syndrome (PCOS) is characterised by irregular periods and increased androgen levels. It is the most common endocrine disorder amongst young women at fertile age, and the most common cause of female infertility. Insulin resistance plays an important role in the development of the disease, and women with PCOS are at increased risk of developing tyoe 2 diabetes. the incretin hormones have not previously been investigated in women with PCOS, and the purpose of the present study was to investigate the secretion of the two most important incretin hormones Glucose-like peptide-1 (GLP-1) and Glucose dependent insulinotropic peptide (GIP) during a three hour oral glucose tolerance test.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 66
- Subjects who fulfill the Rotterdam criteria for PCOS. Age 18-38
- Other endocrine diseases or diseases known to influence glucose/insulin/fat metabolism
- Oral contraceptive administration within three months of study start
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description A metformin -
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method