Effect of High Flow Nasal During Exercise in COPD Patients

Not Applicable

Completed

• Conditions: COPD Exacerbation
• Interventions: Device: High Flow nasal cannula

• Registration Number: NCT03058081
• Lead Sponsor: Groupe Hospitalier du Havre

Brief Summary

Early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (COPD). However, its implementation is challenging particularly as regard exercise training. High flow ventilation in reducing work of breathing and dyspnea may improve exercise tolerance. The aim of this study is to carry out the acute effect of high flow nasal cannula on exercise endurance in post-exacerbation copd patients

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-01-23
• Study First Submitted QC: 2017-02-15
• Study First Posted: 2017-02-20
• Study Start: 2017-08-01
• Status Verified: 2018-05
• Primary Completion: 2018-06-18
• Study Completion: 2018-06-18
• Last Update Submitted: 2018-06-19
• Last Update Posted: 2018-06-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• a diagnosis of COPD

Exclusion Criteria

• exercise contraindication Any musculoskeletal problems, cardiovascular or neurological comorbidities that limits exercise.
• pH < 7,35
• Body temperature > 38°C
• cardiac frequency > 100 bpm at rest
• systolic blood pressure < 100 mmHg
• exacerbation during the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High Flow Nasal Test	High Flow nasal cannula	Patients will perform one Constant Work-Rate Exercise Test at 80% of maximum workload with High Flow Nasal at 60L/min (with or without additional oxygen)

Primary Outcome Measures

Name	Time	Method
Difference in exercise capacity	The outcome will be measure after every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum	Difference in endurance time (TLim) during High Intensity Constant Work-Rate Endurence Test (CWRET)

Secondary Outcome Measures

Name	Time	Method
Difference in peripheral muscle oxygenation	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise	Muscle oxygenation will be evaluated using Near-infrared spectroscopy technology.
Difference in Cardiac Frequency	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise	Difference in Cardiac Frequence using a pulse oximetry
Difference in Dyspnea and muscular fatigue	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be collected every 2 minute during tests and at the end of the exercise	Difference in dyspnea and muscular fatigue using Modified Borg Scale (0 - 10 points)
Difference in Respiratory Muscle Fatigue	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be collected before and 5 minute maximum after exercise	Difference in Respiratory Muscle Fatigue using an electronical manometer
Difference in Oxygen Saturation	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise	Difference in Oxygen Saturation using a pulse oximetry (SpO2)
Difference in Transcutaneous Carbon Dioxide	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise	Difference Transcutaneous Carbon Dioxide using Transcutaneous Carbon Dioxide using a Transcutaneous capnography
Difference in Respiratory Rate	The outcome will be measure during every CWRET. The two CWRET will be carried out in different days, separate from 24H minimum for a total time frame of 3 days maximum. Data will be continuously collected during exercise	Difference in Respiratory Rate using a Respiratory Inductive Plethysmography

Trial Locations

Locations (1)

Groupe Hospitalier du Havre; 🇫🇷 Montivilliers, France