The Effect of HFNC on Exercise Capacity Compared to VM in COPD Patients Recovering From Acute Evacerbation

Not Applicable

• Conditions: COPD
• Interventions: Device: Venturi mask; Device: high flow nasal cannula

• Registration Number: NCT05097560
• Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Brief Summary

Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.

Detailed Description

We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.

Study Timeline

• Study Start: 2021-08-11
• Status Verified: 2021-10
• Study First Submitted: 2021-10-16
• Study First Submitted QC: 2021-10-16
• Last Update Submitted: 2021-10-16
• Study First Posted: 2021-10-28
• Last Update Posted: 2021-10-28
• Primary Completion: 2022-05-31
• Study Completion: 2022-08-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• hospitalized AECOPD patients
• be ambulatory by 48h after admission for AECOPD
• requires oxygen by screening exercise test

Exclusion Criteria

• active coronary ischemia
• respiratory diseases other than COPD
• unstable vital signs
• unstable psychological status

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
VM group	Venturi mask	- Keep FiO2 constant with VM and HFNC during the two trial
HFNC group	high flow nasal cannula	* Set FiO2 28% * Titrate the flow of HFNC at the highest tolerated value up to 60 L/min

Primary Outcome Measures

Name	Time	Method
Endurance time	10 minute	Endurance time for 10 minute steping test

Secondary Outcome Measures

Name	Time	Method
Respiratory pattern	10 minute	Respiratory pattern is calculated by the flow and time
Work of breathing	10 minute	Work of breathing is calculated by the transdiaphragmatic pressure
Neural respiratory drive	10 minute	Neural respiratory drive is calculated by diaphragm electromyogram

Trial Locations

Locations (1)

Shiying; 🇨🇳 Guangzhou, Guangdong, China