Evaluation of severity of coronary artery aneurysm in Kawasaki disease by Z-score of internal diameter

Not Applicable

• Conditions: Kawasaki disease

• Registration Number: JPRN-UMIN000010606
• Lead Sponsor: Tokyo Metropolitan Children's Medical Center

Brief Summary

The aim of this study was to clarify the relationship of the Z-score to time-dependent occurrence of coronary events (CE)in patients with Kawasaki disease (KD) patients with CAA. We surveyed 1006 Kawasaki disease patients < 19 years old who received a coronary angiography. The 10-year event-free survival rate for coronary events was 100%, 94%, and 52% in males and 100%, 100%, and 75% in females for small, medium, and large aneurysms, respectively. Large aneurysms, male sex, and resistance to intravenous immunoglobulin therapy were associated with coronary events.Careful management is essential for males and treatment-resistant patients with large coronary artery aneurysms based on the internal diameter Z-score.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-05-01
• Study Completion: 2014-05-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

Not provided

Exclusion Criteria

1) Echocardiographic data of coronary artery diameters are not available in acute phase. 2) First evaluation of coronary arteries by coronary angiography, enhanced CT,or MRI was done in another institutions. 3) Underlying diseases which affect coronary artery lesions or life prognosis is present.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Optimal cut-off points of internal diameter Z-scores of coronary artery aneurysms for identification of thrombus formation, stenosis, and obstruction.

Secondary Outcome Measures

Name	Time	Method
Optimal cut-off points of internal diameter Z-scores of coronary artery aneurysms for identification of regression or events including angina,myocardial infarction,and cardiac death.