Effect of Remifentanil Administration on Hemodynamic Stability During Placement of a Mayfield Head Fixation Device for Craniotomy
Overview
- Phase
- Not Applicable
- Intervention
- Remifentanil
- Conditions
- Surgery
- Sponsor
- Northwestern University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Mean Arterial Blood Pressure After Head Fixation
- Status
- Terminated
- Last Updated
- 10 years ago
Overview
Brief Summary
To identify a better method using a combination of routine anesthetic drugs to improve hemodynamic stability during Mayfield head pinning for craniotomy surgery.
Detailed Description
A randomized, placebo-controlled, double-blinded comparative effectiveness study to test hypothesis that addition of remifentanil bolus to a standard anesthetic drug regimen will better attenuate the hemodynamic response to the noxious stimulus of Mayfield head pin insertion than the standard anesthetic drug regimen.
Investigators
Laura Hemmer
Assistant Professor of Anesthesiology and Neurological Surgery
Northwestern University
Eligibility Criteria
Inclusion Criteria
- •Adult non-pregnant patients
- •undergoing general anesthesia for a craniotomy
- •requiring a Mayfield head fixation device.
Exclusion Criteria
- •Patients under 18 years of age,
- •non-English speaking,
- •pregnancy,
- •opioid tolerance,
- •illegal drug use or alcohol abuse.
Arms & Interventions
Remifentanil
Intravenous bolus of 10 mL of remifentanil (0.7 mcg/kg based on ideal body weight) will be given ninety seconds before head pinning as well as an intravenous bolus of propofol (0.7 mg/kg).
Intervention: Remifentanil
Normal Saline
Intravenous bolus of 10 mL normal saline from study syringe will be given ninety seconds before head pinning as well as an intravenous bolus of propofol (0.7 mg/kg).
Intervention: Normal Saline
Outcomes
Primary Outcomes
Mean Arterial Blood Pressure After Head Fixation
Time Frame: Ten minute window after head fixation
Secondary Outcomes
- Number of Patients Requiring Rescue Therapy for Hemodynamic Perturbations(10 minute window after head fixation)