Effects of Remifentanil on Breathing Pattern, Respiratory Effort and Gas Exchange in Mechanically Ventilated Patients.
Overview
- Phase
- Phase 4
- Intervention
- remifentanil
- Conditions
- Respiratory Insufficiency
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- respiratory rate/tidal volume
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory pattern and effort in mechanically ventilated patients with rapid shallow breathing or high respiratory rate.
Investigators
Eligibility Criteria
Inclusion Criteria
- •pressure support ventilation or CPAP
- •respiratory rate \> 35.min-1
- •respiratory rate/tidal volume \> 105
Exclusion Criteria
- •vasoactive agents (dopamine lower than 5 mcg.kg-1.min-1 is not considered as vasoactive agent)
- •body temperature \> 38 °C
- •Glasgow Coma Scale \< 9
- •FIO2 \> 0.6
- •PEEP \> 10 cmH2O
- •pH \< 7.30
Arms & Interventions
treatment
Any patient alternatively receive both remifentanil and isotonic saline (placebo)infusion. The order of infusion is randomized. An interval of 30 minutes is planned between the two infusions.
Intervention: remifentanil
treatment
Any patient alternatively receive both remifentanil and isotonic saline (placebo)infusion. The order of infusion is randomized. An interval of 30 minutes is planned between the two infusions.
Intervention: placebo
Outcomes
Primary Outcomes
respiratory rate/tidal volume
Time Frame: before and after remifentanil infusion; before and after placebo infusion.
pressure-time product
Time Frame: before and after remifentanil infusion; before and after placebo infusion.
Secondary Outcomes
- double product of respiratory system(before and after remifentanil infusion; before and after placebo infusion.)
- dynamic intrinsic PEEP(before and after remifentanil infusion; before and after placebo infusion.)
- adverse events(during all the study period)
- arterial pH(before and after remifentanil infusion; before and after placebo infusion.)
- level of sedation (RASS)(before and after remifentanil infusion; before and after placebo infusion.)