NCT01152515已完成4 期
A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The Grade of Coughing During Extubation
研究概览
简要总结
Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil sedated patients after surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Short term ventilator care after surgery in intensive care unit
排除标准
- •chronic obstructive lung disease
- •end stage renal disease
- •risk factors for aspiration
研究组 & 干预措施
Remifentanil
Active Comparator
stopping of propofol and maintenance of remifentanil infusion
干预措施: Remifentanil (Drug)
结局指标
主要结局
The Grade of Coughing During Extubation
时间窗: 2 min
Grade of cough was assessed on a four-point scale (0=no coughing, 1=single cough, 2=more than one episode of nonsustained coughing, 3=sustained and repetitive coughing with head lift).
HR Changes During Extubation
时间窗: 10 min
Mean Arterial Pressure Changes During Extubation
时间窗: 10 min
次要结局
- Time of Extubation(1 hr)
- Time of Awake(1 hour)
研究者
研究点 (1)
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