Does Precise Delivery of Remifentanil Decrease Coughing at Emergence From Anesthesia
概览
- 阶段
- 4 期
- 干预措施
- Remifentanil
- 疾病 / 适应症
- Cough
- 发起方
- University of Vermont Medical Center
- 入组人数
- 60
- 主要终点
- Incidence of cough
- 最后更新
- 7年前
概览
简要总结
The investigators want to find a way to reduce or stop patients from coughing at the end of surgery when the breathing tube is taken out. The breathing tube is removed when the participants are waking up from anesthesia, and are at the point when the participants can breathe on your own. In most types of surgery, coughing at this point is common, and does not affect the participants very much, if at all. But for surgery involving the eye or the head and neck, coughing right after surgery can cause bleeding at the site of surgery.
This study will use a short-acting pain drug called remifentanil at the end of surgery to prevent coughing. The investigators will give the participants this medicine for 5 to 30 minutes. The point of the study is to test if using a simple computer program to guide precise delivery of how much of the drug is given to the participants is effective at reducing or preventing coughing.
研究者
Elie Sarraf
Principal Investigator
University of Vermont Medical Center
入排标准
入选标准
- •Between the ages of 18 and 80
- •Undergoing any of the following elective cases:
- •thyroidectomy (partial or complete)
- •parathyroidectomy
- •ophthalmological surgery
- •Will require endotracheal intubation.
排除标准
- •Lean Body Mass \< 20 kg,
- •Presence of pulmonary dysfunction
- •Any history of anaphylaxis to remifentanil
- •Requiring the use of total intravenous anesthesia.
- •Per the discretion of the anesthesia provider
研究组 & 干预措施
Remifentanil group
Will receive remifentanil bolus and infusion guided by an algorithm
干预措施: Remifentanil
Control group
Will receive normal saline bolus and infusion guided by the remifentanil algorithm
干预措施: Normal saline
结局指标
主要结局
Incidence of cough
时间窗: Measured from surgical end time to patient transfer out of room, approximetly 30 minutes and up to 45 minutes
Notes presence of cough during emergence
次要结局
- Coughing grade(Measured from surgical end time to patient transfer out of room, approximetly 30 minutes)
- Extubation time(Measured from termination of the anesthetic to extubation, approximetly 5 minutes and up to 30 minutes)
- Time to recovery(Measured from extubation to purposeful movement, approximetly 5 minutes and up to 30 minutes)