Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)

Not Applicable

Completed

• Conditions: Female Patients Undergoing Thyroidectomy
• Interventions: Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough

• Registration Number: NCT01351285
• Lead Sponsor: Yonsei University

Brief Summary

It has been reported that target-controlled infusion of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. We hypothesized that effective concentration of remifentanil for preventing cough during anesthetic emergence varies depending on the type of main anesthetic agents which is administered with remifentanil during general anesthesia. The purpose of this study is to evaluate the effective concentrations of remifentanil to prevent coughing during emergence from general anesthesia according to main anesthetic agent (sevoflurane, desflurane, and propofol).

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04
• Study First Submitted: 2011-05-04
• Study First Submitted QC: 2011-05-09
• Study First Posted: 2011-05-10
• Primary Completion: 2011-10
• Study Completion: 2011-10
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-01
• Last Update Posted: 2013-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 78

Inclusion Criteria

• aged 20-60
• ASA classification I~II
• female patients
• patients who undergoing thyroidectomy

Exclusion Criteria

• Patients with acute or chronic respiratory disease
• patient who has smoking history
• patient who has hypertension
• patient who has esophageal reflux
• patient who having an expectorant or cough remedy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevo group	up-and-down method to find out effective concentration of remifentanil for preventing cough	undergoing sevoflurane-remifentanil anesthesia
Des group	up-and-down method to find out effective concentration of remifentanil for preventing cough	undergoing desflurane-remifentanil anesthesia
Pro group	up-and-down method to find out effective concentration of remifentanil for preventing cough	undergoing propofol-remifentanil anesthesia

Primary Outcome Measures

Name	Time	Method
occurrence of cough	From the completion of surgery to 5minute after extubation	We will assess the occurrence of cough during emergence from general anesthesia in female patients undergoing target controlled infusion of remifentanil at predetemined concentration.

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of