Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)
Overview
- Phase
- Not Applicable
- Intervention
- up-and-down method to find out effective concentration of remifentanil for preventing cough
- Conditions
- Female Patients Undergoing Thyroidectomy
- Sponsor
- Yonsei University
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- occurrence of cough
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
It has been reported that target-controlled infusion of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. We hypothesized that effective concentration of remifentanil for preventing cough during anesthetic emergence varies depending on the type of main anesthetic agents which is administered with remifentanil during general anesthesia. The purpose of this study is to evaluate the effective concentrations of remifentanil to prevent coughing during emergence from general anesthesia according to main anesthetic agent (sevoflurane, desflurane, and propofol).
Investigators
Eligibility Criteria
Inclusion Criteria
- •aged 20-60
- •ASA classification I\~II
- •female patients
- •patients who undergoing thyroidectomy
Exclusion Criteria
- •Patients with acute or chronic respiratory disease
- •patient who has smoking history
- •patient who has hypertension
- •patient who has esophageal reflux
- •patient who having an expectorant or cough remedy
Arms & Interventions
Sevo group
undergoing sevoflurane-remifentanil anesthesia
Intervention: up-and-down method to find out effective concentration of remifentanil for preventing cough
Des group
undergoing desflurane-remifentanil anesthesia
Intervention: up-and-down method to find out effective concentration of remifentanil for preventing cough
Pro group
undergoing propofol-remifentanil anesthesia
Intervention: up-and-down method to find out effective concentration of remifentanil for preventing cough
Outcomes
Primary Outcomes
occurrence of cough
Time Frame: From the completion of surgery to 5minute after extubation
We will assess the occurrence of cough during emergence from general anesthesia in female patients undergoing target controlled infusion of remifentanil at predetemined concentration.