The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation

Not Applicable

Completed

• Conditions: Brain Tumor; AVM; ICH
• Interventions: Drug: remifentanil

• Registration Number: NCT01489137
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2011-12-05
• Study First Submitted QC: 2011-12-07
• Study First Posted: 2011-12-09
• Primary Completion: 2012-02
• Status Verified: 2012-08
• Last Update Submitted: 2012-08-15
• Last Update Posted: 2012-08-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients undergoing neurosurgery that require head fixation with mayfield head holder
• patients who agree to our study

Exclusion Criteria

• patients who don't agree to our study
• BMI<16.0 or BMI>30
• cardiovascular disease, pulmonary disease, renal disease
• alcoholic abuser or drug abuser
• patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system
• any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
neurosurgery with fixation	remifentanil	-

Primary Outcome Measures

Name	Time	Method
mean arterial blood pressure	peri-fixation periord	mean arterial blood pressure will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation.
heart rate	peri-fixation periord	heart rate will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation.

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of