The EC50 of Remifentanil Blunting Hemodynamic Response to Double Lumen Tube Intubation

Not Applicable

Completed

• Conditions: Hemodynamic Responses During Tracheal Intubation
• Interventions: Drug: Remifentanil

• Registration Number: NCT01542099
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to evaluate the effect site concentration of remifentanil blunting hemodynamic changes to tracheal intubation of single or double lumen tubes.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2012-02-09
• Study First Submitted QC: 2012-02-24
• Study First Posted: 2012-03-02
• Primary Completion: 2012-04
• Study Completion: 2012-12
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-19
• Last Update Posted: 2016-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients undergoing thoracic surgery that require one lung ventilation

Exclusion Criteria

• patient who does not agree with this study
• BMI < 16.0 or BMI > 30
• cardiovascular disease, pulmonary disease, renal disease
• alcoholic abuser or drug abuser
• patient who takes any drug to influence cardiovascular system or sympathetic nervous system
• any use of local anesthetics or drugs to influence cardiovascular system during tracheal intubation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Single lumen tube	Remifentanil	Single lumen tube intubation during remifentanil infusion
Double lumen tube	Remifentanil	Double lumen tube intubation during remifentanil infusion

Primary Outcome Measures

Name	Time	Method
Changes from baseline in heart rate and mean arterial pressure after intubation	intubation period	Heart rate and mean arterial pressure will be recorded at 2 minutes before intubation, 1 minute before intubation, during intubation, 1 minute after intubation. The mean value of heart rate and mean arterial pressure before intubation will be regarded as the baseline values. If maximum heart rate or mean arterial pressure after intubation increased by \>15% from baseline value, the response will be regarded as "fail" and increased concentration of remifentanil will be applied to next patient by up and down sequential method.

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of