Can quantitative evaluation of pupillary parameters in response to pain stimulation be used for prognostication of acute traumatic brain injury patients - A prospective study
Not Applicable
- Conditions
- Health Condition 1: S064- Epidural hemorrhageHealth Condition 2: S063- Focal traumatic brain injuryHealth Condition 3: S020- Fracture of vault of skullHealth Condition 4: S018- Open wound of other parts of headHealth Condition 5: S068- Other specified intracranial injuriesHealth Condition 6: S066- Traumatic subarachnoid hemorrhageHealth Condition 7: S065- Traumatic subdural hemorrhage
- Registration Number
- CTRI/2024/02/063090
- Lead Sponsor
- IMHANS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All adult patients (18 - 75 years of age), with moderate to severe TBI admitted to Neuro ICU/ward within 48 hours of injury
Exclusion Criteria
1. Absence of feasibility of performing Quantitative Pupillometry(QP) and ONSD assessment on the eye contralateral to the side with significant TBI (contralateral eye with pupillary disease or significant periorbital oedema where pupillary assessment is not possible)
2. Patients for whom consent is not available
3. Patients with significant co-morbidities/ extra cranial injuries where these are likely to affect survival
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association between the magnitude of change in QPi (amplitude of photomotor reflex) to noxious stimulation assessed in the contralateral pupil (opposite to injured side) using automated pupillometry and neurological outcome assessed using Glasgow Outcome Scale Extended (GOSE)Timepoint: 1. at discharge <br/ ><br>2. at 3 months
- Secondary Outcome Measures
Name Time Method