Effect of magnesium sulfate on blood infectio

Phase 2

Recruiting

Conditions: Sepsis.
Gram-negative sepsis, unspecified
A41.50

Registration Number: IRCT20180410039254N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

Critically ill adult patients (18-65 years old) admitted to ICU with diagnosis of sepsis will be included.

Exclusion Criteria

Patients with hypermagnesemia (serum magnesium level> 3.5 mg/dL, hypomagnesemia (serum magnesium level<1.5 mg/dL), renal failure (GFR <30 ml/min /1.73 m2), moderate to severe hepatic insufficiency (child pugh score B, C), seizure , chronic alcohol consumption, malignancy, MAP <65 mm Hg resistant to vasopressors, diabetic ketoacidosis and pregnant women will be excluded.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
actate clearance. Timepoint: At the beginning of the study (before the intervention) and then every 6 hours on the day 0 - Day 1 - Day 2. Method of measurement: By spectrophotometry and Pars-Azmoon kit in mg/dl.;Serum magnesium level. Timepoint: At the beginning of the study (before the intervention) and then every 6 hours on the day 0 - Day 1 - Day 2. Method of measurement: By spectrophotometry and Pars-Azmoon kit in mg/dl.;Intracellular magnesium concentration (RBC magnesium level). Timepoint: At the beginning of the study (before the intervention) and then every 6 hours on the day 0 - Day 1 - Day 2. Method of measurement: By spectrophotometry and Pars-Azmoon kit in mg/dl.

Secondary Outcome Measures

Name	Time	Method
SOFA score (Sepsis-related organ failure assessment score). Timepoint: At the beginning of the study (before the intervention), then daily on day 0 - day 1- day 2. Method of measurement: Based on the SOFA score scale.;APACHE II score ( Acute Physiologic And Chronic Health Evaluation ). Timepoint: At the beginning of the study (before the intervention), then daily on day 0 - day 1- day 2. Method of measurement: Based on the APACHE-II score scale.;Duration of intensive care unit stay. Timepoint: Daily. Method of measurement: Count the number of hospitalization days in the intensive care unit.;Mortality. Timepoint: Daily. Method of measurement: Count the number of dead patients.