Freezing of Gait and Cognition

Completed

• Conditions: Gait Disorder, Sensorimotor; Parkinson Disease; Cognition Disorders
• Interventions: Other: freezers; Other: non freezers

• Registration Number: NCT03477578
• Lead Sponsor: Ospedale Generale Di Zona Moriggia-Pelascini

Brief Summary

The study was aimed to investigate the role of cognition n in FoG.

Detailed Description

Alteration of cortical circuits in PD leads to cognitive dysfunctions associated with the development of FoG.

The study was aimed to investigate the role of cognition in FoG.

Study Timeline

• Study Start: 2017-12-01
• Primary Completion: 2018-02-28
• Study Completion: 2018-03-01
• Study First Submitted: 2018-03-19
• Study First Submitted QC: 2018-03-19
• Study First Posted: 2018-03-26
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-09
• Last Update Posted: 2019-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 305

Inclusion Criteria

• Diagnosis of idiopathic Parkinson's disease according to Gelb et al.

Exclusion Criteria

• Any other neurological conditions other than PD

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
FoG-	freezers	Parkinsonian patients withou Freezing of Gait
FoG-	non freezers	Parkinsonian patients withou Freezing of Gait
FoG+	freezers	Parkinsonian patients with Freezing of Gait
FoG+	non freezers	Parkinsonian patients with Freezing of Gait

Primary Outcome Measures

Name	Time	Method
WCST	5 years	Wisconsin Card Sorting Test
Rey Auditory-Verbal Learning Test	5 years	RAVLT
UPDRS	5 years	Unified Parkinson's DIsease Rating Scale
MMSE	5 years	Mini-Mental State Examination
FAB	5 years	Frontal Behavioural Assessment
TMT A-B	5 years	Trial Making Test A and B

Secondary Outcome Measures

Name	Time	Method
6MWT	5 years	Six-Minute Walk Test
TUG	5 years	Timed Up and Go Test

Trial Locations

Locations (1)

"Moriggia-Pelascini" Hospital; 🇮🇹 Gravedona Ed Uniti, CO, Italy