Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity

Not Applicable

Completed

• Conditions: Aging; Cognitive Impairment; Motor Coordination or Function; Cognitive Decline

• Registration Number: NCT03860441
• Lead Sponsor: Science and Research Centre Koper

Brief Summary

Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group. The investigators tested close (battery of cognitive functions) and far transfer (postural and mobility control, EEG, blood samples) of the CCT. Additionally, the investigators were interested into seeing a long-lasting effect, therefore participants were brought back to the laboratory 1 year post CCT.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-07-01
• Primary Completion: 2018-09-30
• Study Completion: 2018-09-30
• Study First Submitted: 2018-10-02
• Study First Submitted QC: 2019-02-28
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-01
• Study First Posted: 2019-03-04
• Last Update Posted: 2019-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• active and healthy older adults with no major health issues
• members of the Center for Daily Activity Koper (Slovenia)
• had normal or corrected-to-normal vision;
• reported no history of cardiovascular, neurological, or psychiatric conditions

Exclusion Criteria

• younger than 60
• smoking; regular alcohol consumption;
• acute or chronic skeletal, neuromuscular, metabolic and cardiovascular disease condition;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in gait speed	up to 8 weeks	The primary outcome is change in gait speed during single- and dual-task conditions from baseline to post-intervention.

Secondary Outcome Measures

Name	Time	Method
Executive control (Trail-Making Task Forms A and B)	up to 8 weeks	Secondary outcome is change in executive control, measured with TMT A and B tests
Sensorimotor integration measured with EEG/ERP methodology	up to 8 weeks	Secondary outcome is change ERP components P1, N1, P2 and P3 (amplitudes and latencies)
Brain-derived neurotrophic factor (BDNF) extracted from peripheral blood sampling	up to 8 weeks	Secondary outcome is change in plasma BDNF plasma extraction evaluated in pg/mL

Trial Locations

Locations (1)

Center for Daily Activity Koper (Slovenia); 🇸🇮 Koper, Slovenia