Effect of probenecid on boosting cephalexin pharmacokinetics in healthy volunteers

Phase 1

• Conditions: Antibiotic pharmacokinetics; Infection - Other infectious diseases

• Registration Number: ACTRN12613001205729
• Lead Sponsor: Richard Everts

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-11-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Adult
Healthy
Taking no other medication
Normal renal function

Exclusion Criteria

Allergy to cephalosporins, penicillins
Pregnant

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum concentration of free and protein-bound cephalexin, measured by liquid chromatography-mass spectrometry[Tests at baseline, 30 min, 1 hour, 90 min, 2 hours, 150 min, 3 hours, 4 hours, 6 hours, 8 hours and 12 hours]

Secondary Outcome Measures

Name	Time	Method
Side effects (e.g., nausea, rash, headache), measured by questionnaire and direct observation by lead investigator[Monitored continually for 12 hours]