Prediction of outcome in patients with sepsis using Acute phase reactants and sequential organ functional assessment (SOFA) scoring system.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To measure the levels of serum acute phase reactants to reflect the presence and intensity of an inflammatory process in patients with sepsis
研究概览
简要总结
Introduction
Definition
Sepsis - Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection; organ dysfunction is defined as an increase of two or more points in the sequential (sepsis-related) organ failure assessment (SOFA) score.
Septic shock - Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater risk of mortality than sepsis alone; these abnormalities can be clinically identified as all of the following:
Patients who fulfill the criteria for sepsis
Patients who, despite adequate fluid resuscitation, require vasopressors to maintain a mean arterial pressure (MAP)
≥65 mmHg
Patients who have a lactate >2 mmol/L (>18 mg/dL)
Acute phase reactants are elevated in infection, inflammation, trauma and neoplasms. Increasing or persistently high levels suggest a poor prognosis, while declining values are associated with a more favourable prognosis.
In the present study, serum ESR, CRP and PCT concentrations of all patients admitted to ICU with sepsis will be measured and their prognostic value will be compared with SOFA SCORE for the assessment of severity and mortality.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult males or females fulfilling qSOFA Criteria Respiratory rate >22/min GCS<15 SBP<100mmHg.
排除标准
- •Patients with Rheumatic Heart Disorder and Collagen Vascular Disease 2)Patients with malignancy 3)Pregnant women 4)Patients who received antibiotics in prior 7 days.
结局指标
主要结局
To measure the levels of serum acute phase reactants to reflect the presence and intensity of an inflammatory process in patients with sepsis
时间窗: 2 days
次要结局
- To study the mortality in patients with sepsis by correlating the levels of acute phase reactants & SOFA SCORE(2 days)