The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with multiple sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis; Nervous System Diseases; Multiple sclerosis

• Registration Number: ISRCTN15999892
• Lead Sponsor: HS Greater Glasgow & Clyde

Brief Summary

2017 abstract in: https://www.physiotherapyjournal.com/article/S0031-9406(17)30135-9/abstract [added 10/05/2019]

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-02-07
• Study Completion: 2017-07-31
• Last Update Posted: 27 May 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Confirmed diagnosis of progressive MS
2. Aged over 18 years
3. Have an Expanded Disability Status Scale (EDSS) of between 6.5 (Requires two walking aids - pair of canes, crutches, etc - to walk about 20m without resting) and 8.5 (Essentially restricted to bed much of day. Has some effective use of arms retains some self care functions) and spasticity in their lower limbs (self reported).

Exclusion Criteria

1. Cognitive impairment (cannot understand instructions)
2. Other co-morbidities which would preclude them taking part in exercise
3. Visual impairment (such that they cannot see the screen on the APT)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of spasticity on aspects of daily life will be measured using the Multiple Sclerosis Spasticity Scale at baseline and 4 weeks

Secondary Outcome Measures

Name	Time	Method
<br> 1. Spasticity will be measured using The Modified Ashworth Scale (MAS) at baseline and 4 weeks<br> 2. Cardiovascular fitness will be measured using the oxygen uptake efficiency slope (OUES) at baseline and 4 weeks<br> 3. Function will be assessed by the Functional Independence Measure (FIM) and the Timed 25-foot walk test (T25FW) at baseline and 4 weeks<br> 4. Quality of Life will be measured with the MSQOL-54 at baseline and 4 weeks<br> 5. Symmetry, distance cycled and power will be recorded using data collected from the active passive trainer (APT) following each cycling session (intervention group only)<br>