effect of melatonin supplement on oxidative stress
- Conditions
- prediabetes.Abnormal glucose tolerance test
- Registration Number
- IRCT2012110411361N1
- Lead Sponsor
- Vice-chancellor for research -Tehran University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Requirements to select patients:The patients whose affliction with prediabetes are confirmed and their blood sugar before breakfast is in the range of 100-125;age between 35 and 50;BMI = 25 kg/m2;Having normal physical activities ;Interested in the research project
Factors preventing patients from being included in the study ,Smoking, and using alcohol and other drugs ;Professional athletes ,Persons used the drugs reducing blood lipid, heart drugs, hypertension drugs, diuretics, vitamin supplements or any antioxidant three months before the intervention ,Using anti-inflammatory drugs, the drugs or materials having interference with melatonin supplement, such as vafarin, within three months before the intervention ;Having a record of ischemic heart disease, stroke, kidney failure, cancer, chemotherapy, radiotherapy and other diseases in which free radicals are a cause ;Women in the period of pregnancy and breastfeeding;Women with premature menopause;People working at night shifts ;People engaged in shift working
Removing patients from the population:Changing drug diet ;Adopting special diets;Ceasing intake of the supplement for three days
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Activity of SOD enzyme. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,U/gHb,kit.;Activity of CAT enzyme. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,k/gHb,kit.;TAC serum. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,Mmol/ml,kit.
- Secondary Outcome Measures
Name Time Method Blood pressure. Timepoint: befor intervention,1 month after intervention. Method of measurement: Sphygmomanometer,mmHg.;Fasting blood sugar. Timepoint: befor intervention,1 month after intervention. Method of measurement: blood test,Mg/dl.;Height. Timepoint: before intervention. Method of measurement: stadiometer,cm.;Weight. Timepoint: before intervention,30 days after intervention. Method of measurement: Scale ,kg.;BMI. Timepoint: befor intervention,30 days after intervention. Method of measurement: calculate, kg/cm2.