Inspiratory Training and Aerobic Exercise for Muscle Recovery in Myasthenia Gravis Post-Hospitalization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Maximum inspiratory pressure
研究概览
简要总结
The goal of this clinical trial is to determine whether inspiratory muscle training aids in the recovery of respiratory muscle strength and helps prevent further muscle weakness in patients with myasthenia gravis.
The primary research questions are:
Does inspiratory muscle training enhance respiratory muscle strength recovery? Does the intervention lead to improved lung volumes? Participants underwent daily inspiratory muscle training and aerobic exercise for six consecutive weeks.
详细描述
Patients with myasthenia gravis who experience acute exacerbations requiring hospitalization often suffer a significant decline in muscle strength, followed by partial recovery after the acute phase. This randomized controlled trial aims to evaluate the potential of early inspiratory muscle training and aerobic exercise in promoting muscle strength recovery and preventing further weakness. The study will assess differences in lung function, respiratory muscle strength, and dyspnea levels following the intervention after patients are discharged from the hospital post-acute exacerbation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized due to a myasthenia gravis crisis
- •Cleared for discharge from the hospital
- •Capable of completing six weeks of home-based respiratory muscle and exercise training
排除标准
- •Myasthenia Gravis Foundation of America (MGFA) classification I or V
- •Presence of concurrent heart, kidney, liver, or metabolic diseases, or malignant tumors
- •Ability to follow exercise instructions
- •New York Heart Association (NYHA) Class III/IV
- •Pulmonary disease (FEV1/FVC ratio < 0.7 and FEV1 < 50% predicted)
结局指标
主要结局
Maximum inspiratory pressure
时间窗: Six weeks
Maximum inspiratory pressure was measured by instructing each subject to exert their maximum inspiratory force against a pressure gauge.
次要结局
- Dyspnea Severity Assessment(Six weeks)
- Forced expiratory volume at one second(Six weeks)
- Peak expiratory flow(Six weeks)
- Maximum expiratory pressure(Six weeks)
- Forced Vital Capacity(Six weeks)
- Six-minute walk test(Six weeks)
研究者
Hui-Ling Lin
Professor
Chang Gung Memorial Hospital