Effect of Inspiratory Muscle Training on Exercise Performance and Quality of Life in Patients With Chronic Obstructive Pulmonary Disease

Mansoura University0 sites60 target enrollmentOctober 2011

ConditionsChronic Obstructive Pulmonary Disease

Interventionstheophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations peripheral muscles exercise training inspiratory muscle training

Drugstheophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations

Overview

Phase: N/A
Intervention: theophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations
Conditions: Chronic Obstructive Pulmonary Disease
Sponsor: Mansoura University
Enrollment: 60
Primary Endpoint: changes in exercise performance
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Similar Trials

Overview

Brief Summary

The aim is to study effectiveness of inspiratory muscle training as a part of exercise training in patients with Chronic Obstructive Pulmonary Disease (COPD) and if it adds to general exercise training program in regard to respiratory muscle strength, dyspnea, exercise performance and quality of life.

Registry

clinicaltrials.gov

Start Date

October 2011

End Date

April 2014

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Male

Investigators

Sponsor

Mansoura University

Responsible Party

Principal Investigator

Dina Aboelkhair Abdallah

assistant lecturer in chest medicine

Mansoura University

Eligibility Criteria

Inclusion Criteria

•Exsmokers
•Low PImax compared to reference values \[lower limits of normal: 80 cmH2O for patients less than or equal 54 years old; 71 cmH2O for patients' age between 55-64 years; and 65 cmH2O for patients 65 years old \].
•Stable patients without history of exacerbation or hospitalization four weeks before starting the study.

Exclusion Criteria

•Lack of motivation and compliance.
•Patients with significant reversibility following bronchodilation defined as an increase in FEV1 of more than 12% and 200 ml from the pre-bronchodilator value
•Unstable cardiac disease \[severe heart failure, dangerous dysrhythmias, recent myocardial infarction or unstable angina (within 4 weeks)\].
•Uncontrolled hypertension
•Recent pneumothorax (within 6 weeks)
•Recent abdominal or thoracic surgery (within 6 weeks)
•Known progressive neuromuscular disorders
•Recent gastrointestinal bleeding (within 4 weeks)
•Current smokers
•Active cancer

Arms & Interventions

Study group (group A)

pharmacologic treatment: theophylline "uniphyllin", long acting bronchodilators "foradil/spiriva" or combined LABD and inhaled steroids "miflonide" according to GOLD recommendations peripheral muscles exercise training: (upper limb and lower limb strength and endurance training) inspiratory muscle training: (at intensity that progressively increased from 30% to 60% of patients' maximal inspiratory pressure)

Intervention: theophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations

Study group (group A)

Intervention: peripheral muscles exercise training

Study group (group A)

Intervention: inspiratory muscle training

control positive group (group B)

Intervention: theophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations

control positive group (group B)

Intervention: peripheral muscles exercise training

control negative group (group C)

pharmacologic treatment: theophylline "uniphyllin", long acting bronchodilators "foradil/spiriva" or combined LABD and inhaled steroids "miflonide" according to GOLD recommendations

Intervention: theophylline, long acting bronchodilators (LABD) or combined LABD and inhaled steroids according to GOLD recommendations