Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant

Not Applicable

Recruiting

• Conditions: Post-Lung Transplantation Bronchiectasis

• Registration Number: NCT04783155
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, quality of life, and short-term clinical outcomes in patients post lung transplant.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-02-22
• Study First Submitted QC: 2021-03-02
• Study First Posted: 2021-03-05
• Study Start: 2021-05-10
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-10
• Last Update Posted: 2024-12-13
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• All patients who undergo single- or double-lung transplant at Mayo Clinic Florida.

Exclusion Criteria

• Patients who do not survive the intra-operative period during the transplant surgery.
• Patients undergoing retransplantation.
• Patients undergoing multiorgan transplantation.
• Patients who are not willing to or who are unable to give written informed consent.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Maximal inspiratory mouth pressure (MIP) measured in cmH2O	12 weeks	The maximal strength generating capacity of the inspiratory muscles.

Secondary Outcome Measures

Name	Time	Method
Maximal oxygen uptake (V̇O2max) measured in mL/kg/min	12 weeks	Vo2 max is the maximal measured oxygen uptake during a symptom limited exercise test.

Trial Locations

Locations (1)

Mayo Clinic in Florida; 🇺🇸 Jacksonville, Florida, United States