Comparison of the Physical Activity in Cancer Patients Assessed by Questionnaire and Motion Tracker

Recruiting

• Conditions: Lymphoma; Pancreas Cancer; Colorectal Cancer
• Interventions: Other: No intervention - observational study only

• Registration Number: NCT05501379
• Lead Sponsor: University Medicine Greifswald

Brief Summary

Physical activity is an important aspect of cancer therapy but correct measurement of physical activity is difficult. In this study, the physical activity of patients undergoing cancer therapy is assessed by questionnaire and by motion tracker. The results are then compared to answer whether there are differences between the two measurements. Findings of this study will help to improve the assessment of physical activity in cancer patients.

Detailed Description

Although physical activity has been identified as a relevant determinant of cancer therapy outcome, its valid assessment remains challenging. In principle, direct and indirect assessment instruments can be employed for assessment of physical activity. While direct instruments, e.g. accelerometers, are considered to provide a more objective measurement, indirect tools such as questionnaires are less expensive and more applicable for use in larger study populations. The validity of both forms of measurements in cancer patients is however not well studied. Therefore, this study aims to elucidate the relative validity of an accelerometer in comparison to a standardized physical questionnaire at different time points of cancer therapy. Findings of this study will allow conclusions regarding the ideal modalities for assessment of physical activity in cancer patients.

Study Timeline

• Study First Submitted: 2022-08-11
• Study First Submitted QC: 2022-08-11
• Study First Posted: 2022-08-15
• Study Start: 2022-09-21
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-23
• Last Update Posted: 2024-12-27
• Primary Completion: 2024-12-31
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• verified diagnosis of lymphoma, colorectal or pancreatic cancer
• requirement of surgical, chemo or radio therapy
• provision of informed consent

Exclusion Criteria

• pregnancy
• inability to provide consent
• use of a rollator

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cancer Patients	No intervention - observational study only	Patients with a verified diagnosis of lymphoma, colorectal or pancreatic cancer requiring surgical, chemo or radio therapy.

Primary Outcome Measures

Name	Time	Method
Comparison of physical activity assessments within 1 week after initiation of cancer therapy	1 week after initiation of cancer therapy	Difference in physical activity measured by the GeneActiv accelerometer and the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)

Secondary Outcome Measures

Name	Time	Method
Relation of sex to physical activity assessed by questionnaire	1 week after initiation of cancer therapy	Association between sex and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of quality of life to physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between quality of life assessed by the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ C-30) and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Relation of sleep duration to physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between sleep duration measured by the GeneActiv accelerometer in hours and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Relation of sleep efficiency to physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between sleep efficiency, i.e. the ratio of sleep duration to total bed time measured by the GeneActiv accelerometer in hours, and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Comparison of changes in physical activity between assessements within 1 week and 12 weeks after initiation of cancer therapy	12 weeks after initiation of cancer therapy	Difference in changes of physical activity measured by the GeneActiv accelerometer and the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of Karnofsky Performance Status (KPS) to physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between KPS and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Relation of age to physical activity assessed by accelerometer	1 week after initiation of cancer therapy	Association between age and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Relation of fatigue to physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between fatigue assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Fatigue Questionnaire (EORTC QLQFA-12) and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Therapy-related fatigue	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between fatigue assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Fatigue Questionnaire (EORTC QLQFA-12) and cancer therapy modality
Therapy-related sleep efficiency	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between sleep efficiency, i.e. the ratio of sleep duration to total bed time measured by the GeneActiv accelerometer in hours, and cancer therapy modality
Changes in fatigue between assessements before and 12 weeks after initiation of cancer therapy	12 weeks after initiation of cancer therapy	Differences in fatigue assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Fatigue Questionnaire (EORTC QLQFA-12)
Relation of tumor entity to changes in physical activity between assessements within 1 week and 12 weeks after initiation of cancer therapy	12 weeks after initiation of cancer therapy	Association between tumor entity and changes in physical activity measured by the GeneActiv accelerometer and the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Comparison of physical activity assessments 12 weeks after initiation of cancer therapy	12 weeks after initiation of cancer therapy	Difference in physical activity measured by the GeneActiv accelerometer and the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of Eastern Co-operative Oncology Group (ECOG) Performance Status to physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between ECOG Performance Status and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Relation of Eastern Co-operative Oncology Group (ECOG) Performance Status to physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between ECOG Performance Status and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of quality of life to physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between quality of life assessed by the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ C-30) and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Therapy-related quality of life	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between quality of life assessed by the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ C-30) and cancer therapy modality
Relation of fatigue to physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between fatigue assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Fatigue Questionnaire (EORTC QLQFA-12) and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of Karnofsky Performance Status (KPS) to physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between KPS and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of sex to physical activity assessed by accelerometer	1 week after initiation of cancer therapy	Association between sex and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Relation of sleep duration to physical activity assessed by questionnaire	1 week before initiation of cancer therapy, 1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between sleep duration measured by the GeneActiv accelerometer in hours and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of age to physical activity assessed by questionnaire	1 week after initiation of cancer therapy	Association between age and physical activity measured by the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)
Relation of sleep efficiency to physical activity assessed by accelerometer	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between sleep efficiency, i.e. the ratio of sleep duration to total bed time measured by the GeneActiv accelerometer in hours, and physical activity measured by the GeneActiv accelerometer in metabolic equivalents of tasks (METs)
Therapy-related sleep duration	1 week after initiation of cancer therapy, 12 weeks after initiation of cancer therapy	Association between sleep duration measured by the GeneActiv accelerometer in hours and cancer therapy modality
Changes in quality of life between assessements before and 12 weeks after initiation of cancer therapy	12 weeks after initiation of cancer therapy	Differences in quality of life assessed by the European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ C-30)
Relation of cancer therapy modality to changes in physical activity between assessements within 1 week and 12 weeks after initiation of cancer therapy	12 weeks after initiation of cancer therapy	Association between cancer therapy modality and changes in physical activity measured by the GeneActiv accelerometer and the short version of the International Physical Activity Questionnaire (IPAQ-sf) in metabolic equivalents of tasks (METs)

Trial Locations

Locations (1)

University Medicine Greifswald; 🇩🇪 Greifswald, Germany