Effect of computerized cognitive training in dementia with depression: a pilot randomized controlled trial
- Conditions
- Dementia, Depression
- Registration Number
- ChiCTR2400089077
- Lead Sponsor
- CUHK Direct Grant
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion criteria are Chinese individuals aged 65 and older, and having a clinical diagnosis of dementia, as supported by a global Clinical Dementia Rating (CDR) score of 1, and ii) having major depressive disorder (single or recurrent episodes without psychotic features, which occur after the onset of dementia, as supported by scoring above the cutoff in the Cornell Scale for Depression in Dementia, CSDD).
Those with suicidal ideation, psychotic symptoms, or are treatment-resistant (history of electroconvulsive therapy, transcranial magnetic stimulation, or no clinical response to 2 or more different classes of antidepressants) will be excluded and referred to the psychiatric services of the Hospital Authority. Other exclusion criteria are non-Chinese ethnicity, having a history of or ongoing substance abuse, mania, bipolar or psychotic disorder, personality disorder, or depression due to organic causes; having language barrier or impairment in communication due to poor vision or hearing despite correction; or having no family member or carer to escort them to centre for training.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mood symptoms ;
- Secondary Outcome Measures
Name Time Method Cognition;Functioning ;Serum BDNF level ;