Rehabilitation of Reading Deficits in Subacute Stroke Using Functional Magnetic Resonance Imaging (fMRI) Neurofeedback and Motor Imagery
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Kessler Foundation
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Reading Aloud Accuracy
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.
Investigators
Olga Boukrina
Research Scientist
Kessler Foundation
Eligibility Criteria
Inclusion Criteria
- •First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer
- •Age: 18 - 80 years old
- •Fluent and literate in English prior to stroke
- •Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct.
Exclusion Criteria
- •Inability to consent or complete study tasks
- •Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia)
- •A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)
Outcomes
Primary Outcomes
Reading Aloud Accuracy
Time Frame: change from baseline at intervention week 1, 2, and 3
Read aloud 136 words to produce an accuracy score in percent correct.
fMRI Brain Activity
Time Frame: change from baseline at intervention week 1, 2, and 3
Whole-brain and region of interest activation and resting state functional connectivity
Secondary Outcomes
- Reading Comprehension Battery for Aphasia (RCBA-2)(change from baseline at 1 week follow up)
- Western Aphasia Battery-Revised (WAB-R) Bedside(change from baseline at 1 week follow up)
- Boston Naming Test (BNT-short)(change from baseline at 1 week follow up)
- Palm Trees and Pyramids test(change from baseline at 1 week follow up)
- Geriatric Depression Scale (GDS)(change from baseline at 1 week follow up)
- Neuro evaluation(baseline and 1 week follow up)