Thoracic Paravertebral Block : Effect on Acute Pain and Chronic Pain of Hepatectomy With Right J-shape Subcostal Incision
Overview
- Phase
- Not Applicable
- Intervention
- single-injection TPVB + continuous TPVB
- Conditions
- Hepatectomy
- Sponsor
- Cui Xulei
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- cumulative morphine consumption
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection TPVB +continuous(pulsatile infusion) TPVB and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
Investigators
Cui Xulei
Attending physician
Peking Union Medical College Hospital
Eligibility Criteria
Inclusion Criteria
- •Age 18-70 yrs
- •American Society of Anesthesiologists physical statusⅠ-Ⅲ
- •Undergo hepatectomy with J-shape subcostal incision
- •Informed consent
Exclusion Criteria
- •A known allergy to the drugs being used
- •Coagulopathy, on anticoagulants
- •Analgesics intake, history of substance abuse
- •Participating in the investigation of another experimental agent
- •Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
Arms & Interventions
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Intervention: single-injection TPVB + continuous TPVB
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Intervention: Philip CX50 Ultrasound Scanner
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Intervention: PAJUNK Contiplex S Catheter
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Intervention: single dose ropivacaine
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Intervention: continuously infusion of ropivacaine
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Intervention: Morphine given as IPCA
IPCA
postoperative IPCA is given alone
Intervention: Morphine given as IPCA
Outcomes
Primary Outcomes
cumulative morphine consumption
Time Frame: within 48 postoperative hours
Secondary Outcomes
- The pain scores determined by the numeric rating scale (NRS, 0-10)(At 0, 2,4, 8, 12, 24 ,48,72hours and 7day after the surgery)
- nausea and vomiting score(At 0, 2,4, 8, 12, 24 and 48hours after the surgery)
- ambulation time(within the 7 days after surgery)
- patient satisfaction with anesthesia(48 hours after surgery)
- pruritus score(At 0, 2,4, 8, 12, 24 and 48hours after the surgery)
- time of recovery of bowl movement(within the 7 days after surgery)
- Postoperative hospital length of stay(Up to 4 weeks)
- data collection of chronic pain(at 3,6,12 months after surgery)