Thoracic Paravertebral Block : Effect on Acute Pain and Chronic Pain of Hepatectomy With Right J-shape Subcostal Incision
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- cumulative morphine consumption
研究概览
简要总结
This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection TPVB +continuous(pulsatile infusion) TPVB and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-70 yrs
- •American Society of Anesthesiologists physical statusⅠ-Ⅲ
- •Undergo hepatectomy with J-shape subcostal incision
- •Informed consent
排除标准
- •A known allergy to the drugs being used
- •Coagulopathy, on anticoagulants
- •Analgesics intake, history of substance abuse
- •Participating in the investigation of another experimental agent
- •Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
研究组 & 干预措施
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
干预措施: single-injection TPVB + continuous TPVB (Procedure)
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
干预措施: Philip CX50 Ultrasound Scanner (Device)
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
干预措施: PAJUNK Contiplex S Catheter (Device)
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
干预措施: single dose ropivacaine (Drug)
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
干预措施: continuously infusion of ropivacaine (Drug)
Single-injection TPVB +continuous TPVB
Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
干预措施: Morphine given as IPCA (Drug)
IPCA
postoperative IPCA is given alone
干预措施: Morphine given as IPCA (Drug)
结局指标
主要结局
cumulative morphine consumption
时间窗: within 48 postoperative hours
次要结局
- The pain scores determined by the numeric rating scale (NRS, 0-10)(At 0, 2,4, 8, 12, 24 ,48,72hours and 7day after the surgery)
- nausea and vomiting score(At 0, 2,4, 8, 12, 24 and 48hours after the surgery)
- ambulation time(within the 7 days after surgery)
- patient satisfaction with anesthesia(48 hours after surgery)
- pruritus score(At 0, 2,4, 8, 12, 24 and 48hours after the surgery)
- time of recovery of bowl movement(within the 7 days after surgery)
- Postoperative hospital length of stay(Up to 4 weeks)
- data collection of chronic pain(at 3,6,12 months after surgery)
研究者
Cui Xulei
Attending physician
Peking Union Medical College Hospital