Evaluation of association of Parkinsons Disease symptoms with urinary vesicles(exsomes).
- Conditions
- Health Condition 1: G20- Parkinsons disease
- Registration Number
- CTRI/2021/06/033946
- Lead Sponsor
- DrDinesh Upadhya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients will be enrolled from neurology OPD of Kasturba Hospital Manipal.
Patients satisfying the UK PD Brain Bank criteria for idiopathic PD will be included after clinical evaluation by a movement disorder specialist.
Criteria includes bradykinesia and at least 1 of the following
Muscular rigidity; 4-6Hz resting tremor; postural instability not caused by a primary visual
,vestibular,cerebellar or proprioceptive dysfunction following the exclusion of other causes of Parkinsonism.
Additionally, 3 or more features that supported a diagnosis of PD including: a unilateral onset and presence of a resting tremor, a progressive disorder,
Persistent asymmetry maximally affecting the side of onset,
Excellent response to levodopa and presence of severe levodopa induced chorea.
atypical Parkinsonism, secondary Parkinsonism,
h/o repeated Strokes, intake of antipsychotics,mini-mental state examination score <24, presence of cerebral tumor or communicating hydrocephalus,negative response to large doses of Levodopa(if malabsorption is excluded,exposure to 1-methyl4- phenyl2,3,6tetrahydropyridine(MPTP), patients who refused or were unable to give consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In MDS UPDRS, extent and burden of PD will be measured.In MDS NMSS, severity and frequency of NMSs across 9 dimensions will be measured.In urinary Evs, total number of Evs, their size and concentration of proteins will be measured. <br/ ><br>The generated data will help us to understand the association between PD symptoms with urinary EV proteins. If we find a clear association with any specific parameter of EVs with NMS symptoms, further studies can be taken upTimepoint: Urinary exosomes will be isolated immediately.Isolated exosomes will be stored at -80 and analyzed in batches within a week.
- Secondary Outcome Measures
Name Time Method relation of non motor symptoms to motor symptoms will also be statistically analyzed.this will be done in a Tertiary care hospital setting in Manipal,KarnatakaTimepoint: Urinary exosomes will be isolated immediately.Isolated exosomes will be stored at -80 and analyzed in batches within a week. <br/ ><br>it will take 1.5 hours to fill up questionnaire and scale and data collected will be analyzed simultaneously <br/ ><br>