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Clinical Trials/NCT02386579
NCT02386579
Completed
Not Applicable

Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy

Bispebjerg Hospital0 sites5 target enrollmentFebruary 2015
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ConditionsArthropathy, NeurogenicDiabetes ComplicationsDiabetes Mellitus

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Arthropathy, Neurogenic
Sponsor
Bispebjerg Hospital
Enrollment
5
Primary Endpoint
RANKL
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

The study is designed to investigate biomarkers related to bone turnover in diabetics with charcot foot. This is done by measuring local blood samples in the feet, and systemically in a vene and an artery. Measurements are done before and after cooling the feet in icewater to lower the bloodflow.

Patients will be compared with healthy diabetic controls.

Registry
clinicaltrials.gov
Start Date
February 2015
End Date
June 2017
Last Updated
6 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Rasmus Bo Jansen

MD

Bispebjerg Hospital

Eligibility Criteria

Inclusion Criteria

  • •Diabetes mellitus type 1 or 2
  • •Charcot foot diagnosed with x-ray, scintigraphy or clinical review by a specialist

Exclusion Criteria

  • •Osteoporosis
  • •Anti-osteoporotic treatment
  • •Lower extremity amputation
  • •Lower extremity infection

Outcomes

Primary Outcomes

RANKL

Time Frame: 10 min between measurements

Secondary Outcomes

  • sRAGE(10 min between measurements)
  • P1NP(10 min between measurements)
  • osteocalcin(10 min between measurements)
  • CTX-I(10 min between measurements)

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