NCT04333004Unknown1 期
Analysis of Gut Microbiota in Patients With Brain Metastasis of Non-small Cell Lung Cancer Treated by Pembrolizumab Combined With Chemotherapy
Xiaorong Dong0 个研究点目标入组 40 人开始时间: 2020年4月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 40
- 主要终点
- diversity of gut microbiota
研究概览
简要总结
Analysis of Gut Microbiota in Patients With Brain Metastasis of Non-small Cell Lung Cancer Treated by Pembrolizumab Combined With Chemotherapy
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •non-small cell lung cancer patients with less than brain metastases Patients must have received at least the first-line anti-tumor treatment, and the front-line treatment must include chemotherapy or targeted treatment with a platinum containing combination scheme, but not anti-PD-1 / L1 treatment Patients who have not received intracranial local treatment before
排除标准
- •Patients who toke major surgery within 4 weeks prior to enrollment or had ununited wounds Patients with hemorrhage in intracranial metastasis
研究组 & 干预措施
Pembrolizumab Combined With Chemotherapy
Experimental
干预措施: Pembrolizumab Combined With Chemotherapy (Drug)
结局指标
主要结局
diversity of gut microbiota
时间窗: 1 year
Species and abundance of gut microbiota
次要结局
未报告次要终点
研究者
Xiaorong Dong
Professor
Wuhan Union Hospital, China
相似试验
招募中
不适用
Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience ResearchMalignant Central Nervous System NeoplasmNCT06117930Mayo Clinic100
已完成
不适用
Analysis of gut microbiota in patients with neuromuscular syndromes compared to control-groupsG70.0G70.8Other specified myoneural disordersMyasthenia gravisDRKS00017134Klinik für Neurologie, Universitätsmedizin Essen76
招募中
不适用
Gut microbiome dynamics in metastasized or irresectable colorectal cancer: initiating a prospective multicenter cohort10017991colorectal cancerNL-OMON52467niversitair Medisch Centrum Groningen300
招募中
不适用
Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal CancerColorectal Cancer MetastaticNCT03941080University Medical Center Groningen300
Unknown
不适用
Gut Microbiota and Glioblastoma Multiforme PrognosisGut Microbiota, Glioblastoma Multiforme, Microglia, Tumor Related Macrophagocyte, PrognosisNCT03631823Huashan Hospital200