The effects of sildenaphil on oligohydramnios
Phase 2
Recruiting
- Conditions
- Oligohydramnios.Oligohydramnios
- Registration Number
- IRCT20091023002624N21
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 190
Inclusion Criteria
Informed consent
Singleton pregnancy
Gestational age 30-37 weeks
Amniotic fluid index (AFI) less than 5 cm which was discoveredduring third-trimester ultrasonography
Exclusion Criteria
Abnormal fetal Doppler
Fetal anomalies
Fetal growth restriction
Fetal distress like nonreactive non stress test(NST)
Maternal chronic hypertension
Pre-gestational diabetes,
Active labor
Rupture of membranes
Treatment with prostaglandin synthase inhibitors
Maternal diseases contraindicating bolus fluid therapy (kidney, lung, or heart disease)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increasing in amniotic fluid index. Timepoint: at 6 weeks of intervention or before delivery, whichever occurs first. Method of measurement: ultrasonogram.
- Secondary Outcome Measures
Name Time Method Gestational age at delivery. Timepoint: Delivery. Method of measurement: Data sheets.;Rout of delivery. Timepoint: Delivery. Method of measurement: Data sheets.;Neonatal weight. Timepoint: At birth. Method of measurement: Data sheets, gram.;Neonatal Apgar score. Timepoint: At 1 and 5 minutes after birth. Method of measurement: Data sheets.;Umbilical artery pH. Timepoint: at birth. Method of measurement: Data sheets.;Admission to NICU. Timepoint: any time after birth. Method of measurement: Data sheets.;Length of NICU stay. Timepoint: After discharge. Method of measurement: Data sheets, Days.