Paclitaxel in Treating Patients With Recurrent or Persistent Cancer of the Uterus
- Conditions
- Sarcoma
- Registration Number
- NCT00003054
- Lead Sponsor
- Gynecologic Oncology Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with recurrent or persistent cancer of the uterus.
- Detailed Description
OBJECTIVES: I. Estimate the antitumor activity of paclitaxel in patients with metastatic or persistent leiomyosarcoma of the uterus who have failed treatment protocols of higher priority. II. Determine the nature and degree of toxic effects of paclitaxel in this group of patients.
OUTLINE: Patients receive a continuous infusion of paclitaxel once every 3 weeks over 3 hours. Patients in complete remission, partial remission, or stable disease undergo at least 3 courses of paclitaxel. Paclitaxel continues until disease progression or adverse effects prohibit further treatment. All patients are followed until death.
PROJECTED ACCRUAL: This study anticipates an annual accrual of approximately 25 patients over 2.5 years.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (65)
Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States
CCOP - Southern Nevada Cancer Research Foundation
🇺🇸Las Vegas, Nevada, United States
Jonsson Comprehensive Cancer Center, UCLA
🇺🇸Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Chao Family Comprehensive Cancer Center
🇺🇸Orange, California, United States
Women's Cancer Center
🇺🇸Palo Alto, California, United States
Rush-Presbyterian-St. Luke's Medical Center
🇺🇸Chicago, Illinois, United States
Medical College of Georgia Comprehensive Cancer Center
🇺🇸Augusta, Georgia, United States
State University of New York Health Science Center at Brooklyn
🇺🇸Brooklyn, New York, United States
Duke Comprehensive Cancer Center
🇺🇸Durham, North Carolina, United States
State University of New York Health Sciences Center - Stony Brook
🇺🇸Stony Brook, New York, United States
Barrett Cancer Center, The University Hospital
🇺🇸Cincinnati, Ohio, United States
Cleveland Clinic Cancer Center
🇺🇸Cleveland, Ohio, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Simmons Cancer Center - Dallas
🇺🇸Dallas, Texas, United States
University of Massachusetts Memorial Medical Center
🇺🇸Worcester, Massachusetts, United States
North Shore University Hospital
🇺🇸Manhasset, New York, United States
Cancer Center of Albany Medical Center
🇺🇸Albany, New York, United States
Tacoma General Hospital
🇺🇸Tacoma, Washington, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
University of Texas - MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
MBCCOP - Hawaii
🇺🇸Honolulu, Hawaii, United States
CCOP - Upstate Carolina
🇺🇸Spartanburg, South Carolina, United States
NCIC-Clinical Trials Group
🇨🇦Kingston, Ontario, Canada
Albert B. Chandler Medical Center, University of Kentucky
🇺🇸Lexington, Kentucky, United States
CCOP - Evanston
🇺🇸Evanston, Illinois, United States
Cooper Hospital/University Medical Center
🇺🇸Camden, New Jersey, United States
University of Rochester Cancer Center
🇺🇸Rochester, New York, United States
Emory University Hospital - Atlanta
🇺🇸Atlanta, Georgia, United States
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
CCOP - Central Illinois
🇺🇸Springfield, Illinois, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
Johns Hopkins Oncology Center
🇺🇸Baltimore, Maryland, United States
CCOP - St. Francis Hospital/Natalie Warren Bryant Cancer Center
🇺🇸Tulsa, Oklahoma, United States
Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
CCOP - Baptist Cancer Institute
🇺🇸Memphis, Tennessee, United States
University of Pennsylvania Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
Arthur G. James Cancer Hospital - Ohio State University
🇺🇸Columbus, Ohio, United States
Cancer Center, University of Virginia HSC
🇺🇸Charlottesville, Virginia, United States
Vincent T. Lombardi Cancer Research Center, Georgetown University
🇺🇸Washington, District of Columbia, United States
Walter Reed Army Medical Center
🇺🇸Washington, District of Columbia, United States
Memorial Sloan-Kettering Cancer Center
🇺🇸New York, New York, United States
University of Colorado Cancer Center
🇺🇸Denver, Colorado, United States
H. Lee Moffitt Cancer Center and Research Institute
🇺🇸Tampa, Florida, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
University of Oklahoma College of Medicine
🇺🇸Oklahoma City, Oklahoma, United States
CCOP - Greater Phoenix
🇺🇸Phoenix, Arizona, United States
University of Alabama Comprehensive Cancer Center
🇺🇸Birmingham, Alabama, United States
CCOP - Missouri Valley Cancer Consortium
🇺🇸Omaha, Nebraska, United States
CCOP - Columbia River Program
🇺🇸Portland, Oregon, United States
Medicine Branch
🇺🇸Bethesda, Maryland, United States
Radiation Oncology Branch
🇺🇸Bethesda, Maryland, United States
CCOP - Ann Arbor Regional
🇺🇸Ann Arbor, Michigan, United States
CCOP - Kansas City
🇺🇸Kansas City, Missouri, United States
Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Lineberger Comprehensive Cancer Center, UNC
🇺🇸Chapel Hill, North Carolina, United States
Brookview Research, Inc.
🇺🇸Winston-Salem, North Carolina, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
CCOP - Montana Cancer Consortium
🇺🇸Billings, Montana, United States