A Prospective Study on the Effects of Bariatric Surgery on Blood Pressure in Patients With Obesity and Diabetes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Zhiming Zhu
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Reduction of hypertension medication prescription
- Last Updated
- 7 years ago
Overview
Brief Summary
Bariatric surgery is generally recommended for obese people with a body mass index (BMI) of at least 40kg/m2, and for people with BMI 35 kg/m2 and serious coexisting medical conditions such as diabetes. A variety of studies showed that it cause significant weight loss, recovery from diabetes and improvement in cardiovascular risk factors, such as blood pressure. The recent guidelines suggest that patients with a BMI of more than 30 kg/m2 with co morbidities is a candidate for bariatric surgery. However, the patients with diabetes in Chinese has lower BMI than that in west country. Therefore, this research is designed to observe whether bariatric surgery reduce blood pressure in patients with diabetes and relatively lower BMI.
Investigators
Zhiming Zhu
Director of the Dept. of Hypertension & Endocrinology
Third Military Medical University
Eligibility Criteria
Inclusion Criteria
- •Adults aged between 18 and 60 years old.
- •Type 2 Diabetes diagnosis defined according to WHO 2006 guideline.
- •Body mass index between 25.0 and 39.9 kg/m2.
Exclusion Criteria
- •Hypertension ≥ 180/120 mmHg;
- •Type 1 diabetes, other types of diabetes or gestational diabetes;
- •Acute complications of diabetes;
- •Cerebrovascular diseases in the last 6 months.
- •Cardiovascular diseases (myocardial infarction, angina, cardiac failure) in the last 6 months.
- •Baseline psychiatric disorders: schizophrenia, bipolar disorder, severe depression, psychosis.
- •Renal diseases: diabetic nephropathy, creatinine clearance \< 30 ml/min.
- •Advanced peripheral arterial disease
- •Atrophic gastritis
- •Alcoholism or use of illicit drugs
Outcomes
Primary Outcomes
Reduction of hypertension medication prescription
Time Frame: 12 months
Reduction of hypertension medication prescription related to the baseline hypertension treatment at 12 months after surgery.
Secondary Outcomes
- Reduction of hypertension medication prescription(1 month to 6 months)