Effect of gluten diet in Irrtable Bowel Syndrome

Phase 3

• Conditions: Irritable Bowel Syndrome.; Irritable Bowel Syndrome with Diarrhea

• Registration Number: IRCT2013071413996N1
• Lead Sponsor: Digestive Disease Resaerch Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

The study population consist of having IBS based on Rome III diagnostic criteria . Inclusion criteria for the study subjects are: IBS according to Rome III diagnostic criteria of having; age more than 16 years; with informed consent regarding participation in the research project. Exclusion criteria include patients who do not consent to participate in the study; symptoms of gluten-free diet in the first phase of the study; serum Anti TTG positive test; Celiac disease; Pathologic positive CD (Marsh greater than zero) that in patient who (because of positive tests for each of the HLA-DQ2, HLA-DQ8; anti Gliadin Ab (IgG), (IgA) anti Gliadin Ab) underwent endoscopic duodenal biopsy specimens is taken; inflammatory bowel disease; Depression; diabetes; alcohol abuse; none steroidal anti-inflammatory drugs; abnormal levels of glucose; urea; creatinine; sodium; potassium; hemoglobin; ESR and thyroid functional tests.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feeling gas in stomach. Timepoint: BeforE intervention, at the end of the first week till 6th week. Method of measurement: VAS.;Abdominal pain. Timepoint: Before intervention, at the end of the first week till 6th week. Method of measurement: VAS.;Defecation satisfaction. Timepoint: Before intervention, at the end of the first week till 6th week. Method of measurement: VAS.;Nausea. Timepoint: Before intervention, at the end of the first week till 6th week. Method of measurement: VAS.

Secondary Outcome Measures

Name	Time	Method
Fatigue. Timepoint: Before intervention and at the end of 6th week. Method of measurement: VAS.