Assessment of the Tolerability of Dry Airflow in the Nasal Cavity During Sleep
Not Applicable
Withdrawn
- Conditions
- Healthy Adults
- Interventions
- Device: Nasal High Flow
- Registration Number
- NCT02547688
- Lead Sponsor
- Johns Hopkins University
- Brief Summary
Preliminary data show that high flow nasal air has been shown to reduce promote heat exchange due to evaporation of nasal mucus by the air flow resulting in heat loss. It is unclear whether unidirectional nasal airflow is well tolerated in healthy individuals. The central hypothesis of this proposal is that dry high flow nasal air will be sufficiently tolerated in healthy adults.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Healthy men and women
- Able to consent
- Age ≥ 18
- BMI<30kg/m2
Exclusion Criteria
- Previous diagnosis of obstructive sleep apnea or sleep disorder
- History of Constant Positive Airway Pressure treatment for Obstructive Sleep Apnea
- History of recurrent epistasis
- Pregnancy (self-report)
- Deviated nasal septum
- Unstable cardiovascular disease (decompensated Congestive Heart Failure, myocardial infarction or revascularization procedures, unstable arrhythmias)
- Uncontrolled hypertension with BP > 190/110
- Daytime hypoxemia with oxygen saturation<90% (measured at history and physical examination)
- Supplemental oxygen use
- Work in transportation industry as a driver or pilot.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Nasal High Flow Nasal High Flow All subjects are in this group
- Primary Outcome Measures
Name Time Method Subjective Tolerability using Questionnaire Baseline Participant response to nasal high flow using 7 point Likert scale
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Johns Hopkins University
🇺🇸Baltimore, Maryland, United States