The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- University of Chicago
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Measure changes in citrate in urine.
Study Overview
Brief Summary
This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Detailed Description
The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Controls: Adults above the age of
- •Kidney stone patients: Adults above the age of
- •History of majority (>50%) calcium oxalate kidney stones
Exclusion Criteria
- •Anyone with a history of calcium phosphate stones (>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (<30 days), or recurrent urinary tract infections.
- •Any individual who has had ACV outside of normal consumption in the prior month will be excluded.
- •Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.
- •Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.
Arms & Interventions
kidney stone patients and healthy participants
Each participant will be asked to complete a basic metabolic panel prior to initiating the study to ensure that no baseline metabolic derangements exist. On day 1, participants will complete a 24-hour urine collection and 48-hour food diary at home. Participants will then consume an ACV gummy containing 60 meq daily for 14 consecutive days.
Intervention: Apple Cider Vinegar (Dietary Supplement)
Outcomes
Primary Outcomes
Measure changes in citrate in urine.
Time Frame: From Enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measure changes in Urine PH
Time Frame: From enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measure changes in calcium in urine.
Time Frame: from enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measure changes in calcium oxalate in urine
Time Frame: From Enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Secondary Outcomes
No secondary outcomes reported