Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid Using Chair Side(Potential of Hydrogen) pH Meter Assessment Method in Adult Population: Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 28
- 主要终点
- salivary pH
研究概览
简要总结
This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.
详细描述
.28 volunteer participants will be assigned in this study. Participants will be randomly divided into two groups(n=14) according to type of toothpaste D where groups D1 patient will use arginine containing toothpaste while groups D2 the patient will used the fluoride toothpaste with a number of 14 patients in each group. The pH will be evaluated according to time in relation to the brushing with toothpaste (T) where (T0) represent salivary pH before brushing with toothpaste , (T1) represent salivary pH 10 minutes after brushing with toothpaste at fixed time of the day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants should be over 18 years of age.
- •Systematically healthy.
- •Not taking any medication interfering with saliva secretion.
- •Participants who signed informed consent.
排除标准
- •Participants with a compromised medical history.
- •Participants under systemic disease treatment, with antibiotic, steroid or any medication known to cause dry mouth.
- •Severe or active periodontal disease.
- •History of allergies or other adverse reactions to arginine, or oral care product or their ingredient.
研究组 & 干预措施
arginine toothpaste
干预措施: arginine toothpaste (Drug)
fluoride toothpaste
干预措施: fluoride toothpaste (Drug)
结局指标
主要结局
salivary pH
时间窗: 10 minutes after intervention and control
Salivary pH will be determined by use of a digital pH meter .All salivary pH values will be taken immediately following salivary collection at chairside. The salivary pH values measured before usage of toothpaste termed "resting pH," while the salivary pH values measured after usage of toothpaste termed "terminal pH.
次要结局
未报告次要终点
研究者
Laura Yehia
Resident of conservative departement , Faculty of Oral and Dental Medicine, Cairo university,2013
Cairo University