Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid

Not Applicable

• Conditions: Dental Caries
• Interventions: Drug: arginine toothpaste; Drug: fluoride toothpaste

• Registration Number: NCT03143023
• Lead Sponsor: Cairo University

Brief Summary

This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.

Detailed Description

.28 volunteer participants will be assigned in this study. Participants will be randomly divided into two groups(n=14) according to type of toothpaste D where groups D1 patient will use arginine containing toothpaste while groups D2 the patient will used the fluoride toothpaste with a number of 14 patients in each group. The pH will be evaluated according to time in relation to the brushing with toothpaste (T) where (T0) represent salivary pH before brushing with toothpaste , (T1) represent salivary pH 10 minutes after brushing with toothpaste at fixed time of the day.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2017-05
• Study First Submitted: 2017-05-04
• Study First Submitted QC: 2017-05-04
• Last Update Submitted: 2017-05-06
• Study First Posted: 2017-05-08
• Last Update Posted: 2017-05-09
• Study Start: 2017-06
• Primary Completion: 2017-12
• Study Completion: 2018-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Participants should be over 18 years of age.
• Systematically healthy.
• Not taking any medication interfering with saliva secretion.
• Participants who signed informed consent.

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Exclusion Criteria

• Participants with a compromised medical history.
• Participants under systemic disease treatment, with antibiotic, steroid or any medication known to cause dry mouth.
• Severe or active periodontal disease.
• History of allergies or other adverse reactions to arginine, or oral care product or their ingredient.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
arginine toothpaste	arginine toothpaste	-
fluoride toothpaste	fluoride toothpaste	-

Primary Outcome Measures

Name	Time	Method
salivary pH	10 minutes after intervention and control	Salivary pH will be determined by use of a digital pH meter .All salivary pH values will be taken immediately following salivary collection at chairside. The salivary pH values measured before usage of toothpaste termed "resting pH," while the salivary pH values measured after usage of toothpaste termed "terminal pH.