Tissue Penetration of Antibiotics in Obesity

Completed

• Conditions: Obesity

• Registration Number: NCT00752908
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The purpose of this study is to evaluate cefoxitin pharmacokinetics in obese surgical patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-02
• Study First Submitted: 2008-09-12
• Study First Submitted QC: 2008-09-15
• Study First Posted: 2008-09-16
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Results First Submitted: 2018-06-18
• Status Verified: 2019-09
• Results First Submitted QC: 2019-09-05
• Last Update Submitted: 2019-09-05
• Results First Posted: 2019-09-09
• Last Update Posted: 2019-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• BMI <25 and >40
• Scheduled for elective abdominal or pelvic surgery
• Surgical plan for intraoperative cefoxitin prophylaxis
• Able to provide informed consent

Exclusion Criteria

• Allergy to Cefoxitin
• Renal or Hepatic insufficiency

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cefoxitin Plasma Concentrations	8 hours	Cefoxitin plasma concentrations

Secondary Outcome Measures

Name	Time	Method
Cefoxitin Tissue Concentrations	8 hours	Cefoxitin tissue concentrations

Trial Locations

Locations (1)

Barnes Jewish Hospital; 🇺🇸 Saint Louis, Missouri, United States