Investigating the Physiology of Targeted Theta-burst Neuromodulation
Not Applicable
Completed
- Conditions
- Healthy Volunteers
- Registration Number
- NCT02616835
- Lead Sponsor
- Institute of Mental Health Nottingham
- Brief Summary
This research seeks to study the physiological effects of theta-burst transcranial magnetic stimulation (TMS) in the brains of healthy controls using functional MRI and spectroscopy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
- No personal history of neurological or psychiatric disorders
Exclusion Criteria
- Have had a brain injury or neurological disorder
- Have ever suffered an epileptic fit
- Have any non-removable metal implants
- Drink more than 20 units of alcohol per week on a regular basis
- Currently take any illicit drugs on regular basis
- Likely to be pregnant
- Ever suffered from a serious mental illness such as schizophrenia, severe depression or bipolar disorder
- Currently take any psychotropic medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Changes in functional connectivity following TMS administration using functional MRI One hour Changes in brain connectivity will be assessed by comparing functional MRI scans after theta-burst TMS and sham theta-burst TMS
- Secondary Outcome Measures
Name Time Method Changes in brain metabolites following TMS administration using MR spectroscopy One hour Using MRI scans, changes in metabolites in the brain will be assessed following theta-burst TMS and sham TMS
Trial Locations
- Locations (1)
Sarina Iwabuchi
🇬🇧Nottingham, Nottinghamshire, United Kingdom
Sarina Iwabuchi🇬🇧Nottingham, Nottinghamshire, United Kingdom