Proteomics study in patients with severe malaria

Not Applicable

Conditions: Health Condition 1: null- Severe malaria(P vivax and P falciparum)Non malarial feverHealthy participants

Registration Number: CTRI/2013/08/003876

Lead Sponsor: Department of Biosciences and Bioengineering Indian Institute of Technology

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 300

Inclusion Criteria

Participants of either sex aged 18 to 65 years both inclusive

Either gender

with a diagnosis of severe/complicated vivax malaria OR with a diagnosis of severe malaria due to mixed infection

Confirmed nonmalaria fever patients dengue fever (serum IgM antibody titre) leptospirosis (microscopic agglutination test)and enteric fever (widal test)

Healthy volunteers as judged by medical history clinical examination and laboratory investigations

Patients or their legally accepted representatives willing to provide written informed consent

Exclusion Criteria

Patients with history of significant systematic disease like autoimmune disorders chronic liver diseases psychiatric illness and bleeding disorders etc As judged by history and physical examination

Patients with a diagnosis of complications to dengue leptospirosis or any other infectious disease

A female patient who is pregnant at enrolling

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum proteome analysis of patients suffering from severe P vivax and P falciparum malaria infections to get mechnistic insights about disease pathogenesis and host immune response <br/ ><br>Identification of potential serum markers associated with severe versus uncomplicated malaria <br/ ><br>Correlation of the identified serum markers with disease severity establishment of prognostic host markers of malaria <br/ ><br>Timepoint: single time

Secondary Outcome Measures