The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 797
- 试验地点
- 2
- 主要终点
- five year survival
研究概览
简要总结
This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.
详细描述
The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adults undergoing surgery to remove colon cancer
排除标准
- •pregnancy
- •colon cancer with invasion to perineum
- •palliative surgery
- •history of diagnosis or surgery for other cancer
- •emergent surgery
- •ASA PS classification 4 and 5
- •refusion to participate in the study
- •allergy to anesthetics
研究组 & 干预措施
TIVA
propofol infusion targeting bispectral index 40-60
干预措施: Propofol (Drug)
inhalation (Sevoflurane)
sevoflurane targeting bispectral index 40-60
干预措施: Sevoflurane (Drug)
结局指标
主要结局
five year survival
时间窗: five years survival
survival rate regardless of recurrence
次要结局
- 3 year survival(3 years after surgery)
- five year recurrence free survival(five years after surgery)
- 1 year survival(1 year after surgery)
- 1 year recurrence free survival(1 year after surgery)
- 3 year recurrence free survival(3 years after surgery)
研究者
Jin-Tae Kim
Professor (full)
Seoul National University Hospital