The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Propofol
- Conditions
- Cancer of Colon
- Sponsor
- Seoul National University Hospital
- Enrollment
- 797
- Locations
- 2
- Primary Endpoint
- five year survival
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.
Detailed Description
The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.
Investigators
Jin-Tae Kim
Professor (full)
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •adults undergoing surgery to remove colon cancer
Exclusion Criteria
- •pregnancy
- •colon cancer with invasion to perineum
- •palliative surgery
- •history of diagnosis or surgery for other cancer
- •emergent surgery
- •ASA PS classification 4 and 5
- •refusion to participate in the study
- •allergy to anesthetics
Arms & Interventions
TIVA
propofol infusion targeting bispectral index 40-60
Intervention: Propofol
inhalation (Sevoflurane)
sevoflurane targeting bispectral index 40-60
Intervention: Sevoflurane
Outcomes
Primary Outcomes
five year survival
Time Frame: five years survival
survival rate regardless of recurrence
Secondary Outcomes
- 3 year survival(3 years after surgery)
- five year recurrence free survival(five years after surgery)
- 1 year survival(1 year after surgery)
- 1 year recurrence free survival(1 year after surgery)
- 3 year recurrence free survival(3 years after surgery)