The Influence of Type of Anesthesia on Recurrence of Renal Cell Carcinoma After Nephrectomy: a Prospective Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 562
- 试验地点
- 1
- 主要终点
- five year metastasis-free survival
研究概览
简要总结
This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.
详细描述
The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients scheduled for elective nephrectomy due to renal cell carcinoma
排除标准
- •Emergency surgery
- •Pregnancy
- •Allergies to anesthetics
- •Palliative surgery
- •Refusal to participate in the study
- •History of diagnosis or surgery for other cancer
研究组 & 干预措施
TIVA group
Patients receiving the total intravenous anesthesia using propofol
干预措施: Propofol (Drug)
inhalation group
Patients receiving inhalation anesthesia using sevoflurane or desflurane
干预措施: Inhaled General Anesthetics (Drug)
结局指标
主要结局
five year metastasis-free survival
时间窗: five year after surgery
five year metastasis-free survival
次要结局
- one year survival(one year after surgery)
- five year survival(five year after surgery)
- one year metastasis-free survival(one years after surgery)
- three year metastasis-free survival(three years after surgery)
- three year survival(three year after surgery)
研究者
Jin-Tae Kim
professor
Seoul National University Hospital