Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Congenital Heart Disease
- Sponsor
- Huiying Shao
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- renal blood flow
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
Detailed Description
Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.
Investigators
Huiying Shao
The attending anesthesiologist
Children's Hospital of Fudan University
Eligibility Criteria
Inclusion Criteria
- •children with congenital heart disease
- •\<3 years of age
Exclusion Criteria
- •preoperative renal insufficiency;
- •renal malformation, kidney absence
Outcomes
Primary Outcomes
renal blood flow
Time Frame: 2 days
Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)
Secondary Outcomes
- creatinine(3 and 4 days)
- Mean arterial pressure(2 days)
- cardiopulmonary bypass (CPB) time(24 hours)
- neutrophil gelatinase-associated lipocalin , NGAL(2 days)