"Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail

Not Applicable

Completed

• Conditions: Kidney Donation/Transplantation
• Interventions: Drug: volatile agent only during reperfusion; Drug: propofol-remifentanil/sufentanil

• Registration Number: NCT01248871
• Lead Sponsor: University Medical Center Groningen

Brief Summary

To compare the renal protective properties of two currently used anaesthetic techniques - a sevoflurane-remifentanil/sufentanil combination with a propofol-remifentanil/sufentanil combination for anaesthesia in patients undergoing living donor kidney donation/transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2010-11-24
• Study First Submitted QC: 2010-11-24
• Study First Posted: 2010-11-25
• Primary Completion: 2012-10
• Study Completion: 2012-10
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-16
• Last Update Posted: 2024-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• All patients: Age > 18 years

Exclusion Criteria

• patient refusal
• BMI< 17, >35
• neurological disorder
• recent use of psycho-active medication, including alcohol.
• Donor-recipient couples from the ABO-incompatible program
• Altruistic donor

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
SERE	volatile agent only during reperfusion	volatile agent only during reperfusion
propofol	propofol-remifentanil/sufentanil	propofol-remifentanil/sufentanil

Primary Outcome Measures

Name	Time	Method
To compare the renal protective properties of two currently used anaesthetic techniques	participants will be followed for the duration of hospital stay

Trial Locations

Locations (1)

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands