Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery
Phase 4
Completed
- Conditions
- Aortic DiseasesAbdominalAneurysmSurgery
- Interventions
- Registration Number
- NCT00538421
- Lead Sponsor
- Sykehuset i Vestfold HF
- Brief Summary
Comparing 2 different anaesthetic methods during abdominal aortic aneurysm surgery. The patients will be followed up 30 days postoperative. Number of patients included will be 200. Perioperative details will be analyzed.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 193
Inclusion Criteria
- Patients who are planned for open, elective abdominal aortic aneurysm surgery.
- ASA group 1-4.
Exclusion Criteria
- Patients below 18 years.
- Patients who are included in other pharmaceutical studies.
- Opioids-, benzodiazepins-, antiepileptic drugs-, alcohol- and α2-agonists abuse.
- Pregnant and breastfeeding women.
- Patients with familiar history of malignant hyperthermia.
- Patients with known hypersensitivity for opioids, propofol or volative anaesthetics.
- Patients with considerable arrythmia (atrial fibrillation /atrial flutter is acceptable). Uncontrolled hypertension, serious psychiatric disease.
- Patients with unstable angina pectoris or myocardial infarction last month before inclusion.
- Acute abdominal aortic surgery. Acute dissection or rupture.
- Planned laparoscopic abdominal aortic aneurysm surgery.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Propofol - 2 Sevoflurane -
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which sevoflurane interacts with opioid receptors in abdominal aortic aneurysm surgery?
How does the combination of remifentanil and propofol compare to sevoflurane in managing postoperative pain after abdominal aortic aneurysm repair?
Which biomarkers are associated with improved outcomes in patients receiving sevoflurane-based anesthesia for aortic aneurysm procedures?
What are the potential adverse events of opioid-potentiated volatile anesthesia versus remifentanil-propofol in aortic surgery patients?
How do sevoflurane and propofol compare in their impact on postoperative cognitive dysfunction in abdominal aortic aneurysm surgery?
Trial Locations
- Locations (1)
Sykehuset i Vestfold HF
🇳🇴Tonsberg, Norway
Sykehuset i Vestfold HF🇳🇴Tonsberg, Norway